Zinedine Zidane has picked Isco again after using him against Atalanta in the Champions League last Wednesday.
The Spanish midfielder had not started in La Liga since November 8, 2020, but lines up from the off against Real Sociedad on Monday night.
Vinicius is sacrificed from the line up with Mariano also starting.
Zidane has Fede Valverde, Odriozola, Marcelo and Rodrygo back from injury for the game but all start on the bench.
The line ups are as follows:
Real Madrid: Courtois, Lucas Vázquez, Varane, Nacho, Mendy, Modric, Casemiro, Kroos, Marco Asensio, Mariano, Isco.
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Real Sociedad: Remiro, Gorosabel, Zubeldia, Le Normand, Monreal, Guevara, Zubimendi, David Silva, Portu, Isak, Oyarzabal.