Santiago Solari has so many injury problems in his squad he may have to start Isco against Real Betis. Without Llorente, Kroos, Asensio, Mariano and Bale, as well as the suspended Lucas Vazquez, and Vinicius possibly out with flu, Isco is one of the few players remaining.
Only two variables could stop that - Solari deciding to use Fede Valverde or Brahim Diaz instead.
Casemiro-Modric-Ceballos-Isco could be the midfield used by Solari.
Isco hasn't started a game in La Liga since October 28, at Camp Nou, the last match under former coach Julen Lopetegui.
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Under Solari he has started just twice - against Melilla in the Copa del Rey and against CSKA Moscow in the Champions League.