Espanyol were drawn against Wolverhampton Wanderers in Monday's Europa League last 32 draw, one of the most intense sides in the Premier League this season.
Former Valencia coach Nuno Espirito Santo is in charge of Wolves. He has led them from the Championship into the Premier League and then into Europe.
Wolves usually play with a back five and boast a number of impressive attackers, including the former Atletico Madrid striker and Mexico international Raul Jimenez.
There was also a tough draw for Getafe, who were paired with last season's Champions League semifinalists Ajax. Sevilla, the other Spanish side in the competition will take on Romanian side Cluj.
Europa League last-32 draw
Apoel v Basel
AZ Alkmaar v LASK
Bayer Leverkusen v Porto
Brugge v Manchester United
Cluj v Sevilla
Copenhagen v Celtic
Eintracht Frankfurt v RB Salzburg
Getafe v Ajax
Ludogorets v Internazionale
Olympiakos v Arsenal
Rangers v Braga
Roma v Gent
Shakhtar Donetsk v Benfica
Sporting v Istanbul Basaksehir
Wolfsburg v Malmö
Wolves v Espanyol
First legs take place 20 February, second legs 27 February