Quique Setien is taking on his most testing week since joining FC Barcelona, with double stress against Napoli then Real Madrid. The team will welcome Frenkie de Jong back and will likely line up 4-4-2 against Napoli.
Barcelona walked past Eibar 5-0 and De Jong was rested for most of the game. Busquets, De Jong, Arthur and Arturo Vidal could form a midfield rhombus, while Ivan Rakitic is an option too, possibly ahead of the Brazilian.
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There's not much flexibility in defence or attack. Messi and Griezmann will start up front. At the back Sergi Roberto and Jordi Alba are injured, so Nelson Semedo and Junior Firpo will be the full backs. Gerard Pique will likely be paired with Clement Lenglet. In goal? Ter Stegen.