FC Barcelona coach Quique Setien has named his 18-man squad list for the match against Leganes in the Copa del Rey.
Messi, Piqué and Busquets were rested for the previous round's match away to Ibiza but all of them are recalled for the test against LaLiga opposition.
Young pair Ansu Fati and Àlex Collado, alongside Iñaki Peña, are also named in the squad.
However Riqui Puig, who missed the trip to Valencia through illness, won't be involved.
Full squad list: Ter Stegen, Semedo, Piqué, Rakitic, Busquets, Arthur, Messi, Lenglet, Griezmann, Alba, Sergi Roberto, De Jong, Vidal, Umtiti, Junior, Peña, Collado and Ansu Fati.